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New neutralising antibodies discovered

Richard Jefferys, TAG A paper just published online by Science Express reports the discovery of two new antibodies capable of neutralising a broad array of diverse HIV strains. The antibodies interact...

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Aging, HIV infection and the immune system

Richard Jefferys, TAG In the November 9th issue of New York Magazine, David France reports on the emerging issue of accelerated aging in people with HIV infection. The article offers a series of...

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Free journal on immunology and cardiovascular disease

Richard Jefferys, TAG The January 2010 issue of the journal Clinical Immunology is offering free access to a series of articles addressing the immunology of cardiovascular disease. Among a range of...

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Bridging the neurology-immunology barrier

Richard Jefferys, TAG The Cell Press journals Neuron and Immunity have collaborated to produce a timely free-access special issue focusing on the interrelatedness of neural and immune systems. [1] The...

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Early predictors of disease progression

Richard Jefferys, TAG Recent research involving SIV-infected macaques has suggested that the early loss of a particular type of memory CD4 T cell (known as a “central memory” T cell or Tcm) may be a...

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Has poor CD4 T cell reconstitution in the gut been exaggerated?

Richard Jefferys, TAG In recent years, loss of CD4 T cells from the gut of HIV-positive people has become a major research focus. Gut CD4 T cell depletion happens rapidly after infection, and many...

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Baseline naive CD4 T cell numbers predict the immunological response to ART

Richard Jefferys, TAG The loss of naivet矴hat comes with getting older is familiar to just about everyone. Somewhat less familiar is the fact that this is also true immunologically; our repertoire of...

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Sex and the single microbicide

Richard Jefferys, TAG The levels and distribution of an anti-HIV microbicide in the genital tract are likely to be critical factors in determining potential efficacy. Up until now, research studies...

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Early predictors of disease progression

Richard Jefferys, TAG Recent research involving SIV-infected macaques has suggested that the early loss of a particular type of memory CD4 T cell (known as a “central memory” T cell or Tcm) may be a...

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Pre-infection CD8 T cells targeting HIV linked to lower post-infection viral...

Richard Jefferys, TAG The research group of Francis Plummer at the University of Manitoba was among the first to document evidence that some people can resist HIV infection despite multiple exposures....

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Coagulation and inflammatory biomarkers in children and adolescents with HIV

Richard Jefferys, TAG The Strategies for the Management of AntiRetroviral Therapy (SMART) trial has transformed HIV research by unambiguously demonstrating the link between viral replication,...

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Cell-free vs cell-associated HIV transmission

Richard Jefferys, TAG One of the most difficult questions to address regarding HIV transmission is whether virus floating free in plasma (cell-free virus) or contained inside cells (cell-associated...

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Bad to the bone marrow?

Richard Jefferys, TAG The extent to which HIV may infect CD34+ hematopoietic progenitor cells (stem cells) in the bone marrow has been the subject of controversy for more than two decades. [1] Early...

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The antiviral impact of CD8 T cells: much ado about the mechanism

Richard Jefferys, TAG The primary mechanism by which CD8 T cells contribute to controlling pathogens is by killing infected cells. The afflicted cells display pathogen epitopes on their surface via...

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HIV persistence, raltegravir/maraviroc intensification and immunology

David Margolis MD, University of North Carolina, for NATAP Persistent HIV infection despite successful ART Ultimately, we must either acquiesce to treat HIV patients with ART forever, or find ways to...

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Immune-based therapies and preventive technologies pipeline

Richard Jefferys Unlike the other pipelines discussed in this report, there are no approved immune-based therapies or biomedical preventive technologies for HIV— aside from antiretroviral therapy...

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Antiretroviral therapy dramatically reduces HIV transmission

Richard Jefferys, TAG A recent posting linked to the abstract of a study evaluating the impact of ART on HIV transmission that was presented at CROI earlier this year. The full results have now been...

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HIV infection, inflammation and premature ageing

Webcasts from a symposium on this topic, held on 18 May 2010 by the Center for AIDS Research at the University of California at San Francisco, are available online....

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Signs of progress in gene therapy for HIV

Richard Jefferys, TAG Until recently, the idea of genetically modifying a person’s immune system to make it resistant to HIV was generally viewed as extremely appealing, but so dauntingly impractical...

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Rapporteur summaries

Immediately prior to the main IAS conference there was a two-day meeting with an excellent programme focusing on the growing body of research looking at targeting the HIV viral reservoirs, both tissue...

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